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Tails of histones lost
References: 13 Times Cited: 0
Author(s):
Abstract:
A double-stranded break in DNA can profoundly destabilize a cell's genome. But how does the cell recognize the damage and halt division until it can be fixed? The answer lies in the proteins that package and unravel DNA. DNA damage induces cell-cycle checkpoints that transiently arrest progression through the cell-division cycle. This delay gives the DNA-repair machinery sufficient time to fix genomic damage before the cell cycle resumes. Two studies, one by Tsukuda et al. published at the end of last year and one by Keogh et al. in this issue (page 497), demonstrate that modifications to the DNA packaging around the break site help to coordinate DNA repair with cell-cycle checkpoints.
Source:
Nature , 2006, 439 (7075) : 406-407
ISSN:
0028-0836
Language:
English
参考文献 13 篇 共 3 页 现在第 1 页 第一页 前一页 下一页 最后一页
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